Equipment Status

Laser Doppler System

Equipment Description

A modular medical device used to non-invasively assess human microcirculation, including tissue blood perfusion and oxygen supply.
This assessment method is used in clinical and research settings to evaluate conditions such as peripheral arterial disease, diabetic foot disease, and wound healing.

Components & Performance

A key feature of this system is its modular design, allowing users to customize it by adding up to four functional units to meet specific clinical or research requirements.
Multifunctional and compact: The system is designed to be user-friendly and compact, performing various measurements with a single device, saving space and enhancing portability.
Simultaneous monitoring: Multiple parameters can be monitored simultaneously at several sites on a patient, and data can be easily downloaded to a PC for analysis and reporting.
Non-invasive measurement: The system primarily utilizes non-invasive technologies such as laser Doppler and transcutaneous sensors, which are designed to be safe for the patient.
Probe types: The product supports a variety of fiber-optic and flexible probes, including heated probes for maximal blood flow induction, aiding in the assessment of endothelial function.

Non-Invasive Blood Pressure Measurement System for Rodents

Equipment Description

This system is designed to non-invasively measure blood pressure in rats and mice, providing data on systolic, diastolic, and mean blood pressure as well as heart rate.

Components & Performance

A simple and reliable technique for measuring systemic blood pressure and cardiovascular parameters in rodents without invasive catheter insertion. It provides complete reliability for performing continuous measurements on the same animal. Analog signal output for recording cuff pressure and pulse signals on a PC. An automatic deflation system that operates individually for each animal (minimizing tail injury). Automatic cuff inflation/deflation at a very constant rate. The same system can be used for rats/mice. Provides actual values (no linear regression calculation). Easily traceable data (using data acquisition software). The evaluated parameters can be visualized online via a digital display.

Non-Invasive Blood Pressure Measurement System for Rodents

Equipment Description

The Non-Invasive Blood Pressure (NIBP) measurement system for rodents (mice, rats) utilizes tail-cuff oscillometric technology to measure systolic pressure, diastolic pressure, and heart rate while minimizing stress to the animal.
It measures by occluding tail blood flow and then reducing the cuff pressure, and is mainly used as a blood pressure analysis system for small research animals.

Components & Performance

A simple and reliable technique for measuring systemic blood pressure and cardiovascular parameters in rodents without invasive catheter insertion. It provides complete reliability for performing continuous measurements on the same animal. Analog signal output for recording cuff pressure and pulse signals on a PC. An automatic deflation system that operates individually for each animal (minimizing tail injury). Automatic cuff inflation/deflation at a very constant rate. The same system can also be used for rats/mice. Provides actual values (no linear regression calculation). Easily traceable data (using data acquisition software). The evaluated parameters can be visualized online via a digital display.

Individually Ventilated Cage Rack

Equipment Description

A specialized laboratory animal housing system that supplies filtered air directly to each cage, improving air quality, reducing noise/vibration, and providing excellent protection from contamination.
These racks are mainly used for rodent housing,
and are housing equipment featuring a high-density design (up to 192 or more positions), dual HEPA filters, positive/negative pressure modes, and, in some systems, the ability to use building exhaust air without a motor.

Components & Performance

Key features of the IVC rack system - Contamination control: Provides a sterile environment for the animals (positive pressure) or blocks the spread of infectious pathogens (negative pressure).
Airflow and ventilation: Each cage is individually ventilated to remove odors and allergens, typically using HEPA-filtered supply and exhaust systems.
High-density design: Accommodates large numbers of cages using single-sided or double-sided racks, maximizing laboratory space efficiency.
Maintenance and ergonomics: Modern systems are designed to be lightweight and easy to clean, often featuring automatic watering or monitoring functions.
Compatibility: Racks are generally designed to be compatible with both stainless steel cage systems and disposable plastic cage systems.

Pulmonary Research System for Laboratory Animals

Equipment Description

The flexiVent pulmonary function measurement solution is widely recognized as the standard for in vivo respiratory mechanics measurement.
This solution goes beyond conventional lung ventilation resistance and compliance mechanics to capture important detailed information about the mechanical properties of the airways, distal airways, and lung parenchyma.
By precisely controlling experimental conditions, flexiVent achieves the highest sensitivity and reproducibility.

Components & Performance

Mice with fibrosis showed a typical restrictive lung disease pattern, with reduced PEF and FVC and a normal FEV0.1/FVC ratio. Mice with emphysema showed a reduced peak expiratory flow (PEF), a characteristic of the obstructive phenotype. Mice with acute lung injury showed a markedly reduced PEF. Mice with asthma symptoms showed a reduced FEV0.1 after methacholine administration.

Deep Wrinkle Measurement Device for Skin

Equipment Description

In the cosmetics and pharmaceutical industries, research into the measurement of skin wrinkles-essential for efficacy testing and claim support, particularly in the anti-aging field-is being conducted.
For over 40 years, the cosmetics industry has investigated this parameter.
Although in vivo approaches to wrinkle depth have been steadily studied, measuring directly on living skin is not easy
due to its constant variability (pulse, muscle movement, respiration), so many scientists tend to return to the long-established replica analysis method of the skin surface.
The measurement principles based on these facts are called the profilometry method. In Visioline, the skin replica is
illuminated with indirect light, and the mountains of the replica (which reproduce the skin's wrinkles) are converted into digital form through a high-resolution camera, creating measurable shadows.
This serves as the basis for various arithmetic measurement methods. This analysis method is particularly suitable for observing deep wrinkles, e.g., “crow feet”.

Components & Performance

• Visioline® VL 650 with illumination source and camera
• Software CD
• USB connection cable to connect the device to computer
• External power supply with power cable
• Dongle protection module
• Kit to produce 100 silicone replica:- special double sided stickers - special paper frames- set of Silflo replica material - stirring cups- stirring rods
• Calibration slides
• 100 Corneofix® F 20 and 100 Sebufix® F 16 (special foils to evaluate sebum and desqua- mation)
• Instruction manual

Laser Microvascular Blood Flow Imaging Device

Equipment Description

PeriCam PSI converts tissue blood flow into a real-time blood flow unit data stream. To facilitate data interpretation, the application software (PIMSoft) visualizes the measurement area in color.
In a blood flow imaging of an animal with a tail ulcer, the blue areas indicated by color a lower blood flow than the green and yellow areas.
That is, the blood flow at the wound site is low, while the surrounding area has high blood flow.
PeriCam PSI offers a variety of color-coding schemes that can be configured to match the user's experimental environment or established best practices.

Components & Performance

Easy to use - It is non-contact, non-invasive, and non-destructive.
Visualization — Perfusion graphs, color-coded images, and videos facilitate data interpretation.
Robust data — Accurate, repeatable, and objective data points supporting analysis and long-term studies. To facilitate analysis, Regions of Interest (ROI) are created before, during, and after recording, and Times of Interest (TOI) are created after recording.
High temporal resolution - Image capture frequency of up to approximately 100 images per second.
Spatial resolution — 10 μm/pixel (PeriCam PSI HR), 33 μm/pixel (PeriCam PSI NR).
Sensitivity — The ability to detect subtle changes in blood flow.
Continuous autofocus (only on some models) - A setup function that compensates for tissue movement or changes in device position so that all images are sharp and accurately focused on the measurement area.
Automatic ambient light correction - Ensures stable measurements under various lighting conditions.
High-quality robotic arm - Excellent maneuverability and stability prevent errors caused by movement.
Wide-angle recording camera - Simplifies post-measurement analysis.
Color coding — The default color scheme can be adjusted to match the user's workflow and established standards. Non-invasive, non-contact, non-destructive. PeriCam PSI is built on non-invasive and contact-free design principles, making it ideal for measuring blood flow in environments where contact-based measurement techniques are not feasible, such as wounds or surgical sites. This technology does not require contrast agents or tracers, reducing the clinical workload, simplifying the measurement process, and minimizing the impact on patients and study participants. Due to its non-contact and non-invasive design, PeriCam PSI is a non-damaging tool that prevents damage to sensitive tissue and minimizes the impact on the subject.

Optical Imaging System for Small Animals

Equipment Description

Overview: The IVIS Lumina S5 in vivo imaging system has all the capabilities of the existing IVIS Lumina platform and is ideal for accelerating research by streamlining the imaging workflow, data acquisition, and analysis through improved throughput and accessories.
High-throughput, high-sensitivity optical imaging: The IVIS Lumina S5 integrates a next-generation 1-inch CCD camera into a benchtop instrument, providing a high-throughput field of view (FOV) of 20 x 20 cm-large enough to image five animals at once for bioluminescence and fluorescence in vivo imaging.
Like other IVIS Lumina in vivo optical imaging systems, the IVIS Lumina S5 features 26 tunable filters capable of imaging fluorescent sources emitting from green to near-infrared.
Innovative illumination technology effectively enhances fluorescence transmission up to 900 nm.
In addition, the IVIS Lumina S5 incorporates Revvity's patented Compute Pure Spectrum (CPS) algorithm, ensuring accurate autofluorescence removal, unmixing, and fluorophore quantification through spectral library generation software tools.
The absolute calibration provided as standard on all IVIS instruments delivers consistent and reproducible results with any other IVIS instrument-within a tissue or anywhere in the world-regardless of magnification or filter selection.

Components & Performance

Key features: High-throughput (5 animals) optical imaging. Increased throughput using an optional manifold (10 mice). Supports imaging of mice and rats. CPS (Compute Pure Spectrum) spectral unmixing. Tunable fluorescence intensity across the near-infrared spectrum. Specialized accessories to speed up data acquisition and analysis. Takes up little space; can be placed on a countertop. IVIS systems are provided with a free Living Image software license, also available upon request.

Mobile X-ray Fluoroscopy Device

Equipment Description

This equipment has an optional vascular angiography function, enabling angiography of various blood vessels and cardiovascular structures in operating rooms such as vascular surgery, thoracic surgery, and radiology,
and can be used for intervention procedures. This equipment is based on
pulse X-ray technology capable of low-dose imaging and features a rotation tube and high-power boost caps, so it can be used in all regions such as
bone, abdominal, and heart during animal experiments. In particular, the vascular function can be used for high-end vascular, cardiovascular, cardiac, and hybrid room applications.
Vascular angiography imaging provides DSA, MSA, and RSA (roadmap) functions, and allows angiography imaging at up to 25 frames per second per pixel, so in the operating room
this equipment can be used for various vascular-related surgeries and interventional vascular procedures in vascular surgery and thoracic surgery.
It is also equipped with pixelshift and landmarking functions and single-image capability to obtain clear images.

Components & Performance

A flat-panel C-arm equipped with a 30 x 30 cm a-Si and 20.5 x 20.5 cm, 31 x 31 cm CMOS flat panel detectors, allowing flexible proposals for the intended use, providing true digital images. Equipped with ODDC (Object Detected Dose Control) and ZAIP (Ziehm Adaptive Imaging Processing). Equipped with a 25 kW high-capacity generator technology and pulse X-ray technology. Features a touch panel interface and Ziehm's proprietary Smart Vascular function.

X-ray Tomography System for Small Animals

Equipment Description

A micro-CT imaging application for the bone, oncology, cardiovascular, and lung functions of live animals, enabling longitudinal studies.
Bone research: Quantifies bone mineral density, microstructure, and the healing process.
Oncology: Monitoring of tumor growth, nanoparticle proliferation, and treatment response.
Cardiovascular and lung: Imaging of pulmonary fibrosis, asthma models, and vascular structures using contrast agents.
Dentistry: Detailed structural imaging of teeth and implants.

Components & Performance

Key features and functions - Various imaging capabilities: Supports both in vivo longitudinal imaging (observing the same animal over time) and high-resolution ex vivo scans.
High resolution and high speed: Provides spatial resolution down to a 2.3 μm voxel size, and scans can be completed in just 3.9 seconds.
Low-dose technology: Designed for low X-ray doses, essential for maintaining the health of live animals during long-term studies.
Multiple species support: Can accommodate a variety of animals including zebrafish, rats, mice, guinea pigs, and small rabbits using bores ranging from 18 mm to 120 mm.
Gating technology: A two-stage retrospective respiratory and cardiac gating function compensates for image distortion caused by movement, enabling high-quality imaging of the lungs and heart.
Multimodal integration: Seamlessly co-registers with the optical signals of IVIS Spectrum or FMT systems, allowing the combination of anatomical CT data with functional bioluminescence or fluorescence data.

Diagnostic Ultrasound Device

Equipment Description

An advanced diagnostic ultrasound system developed by Mindray, used as a veterinary ultrasound and providing 3D/4D imaging (iLive). Through "exceptional clarity" and "exceptional intelligence," it provides diagnostic accuracy and efficiency from pregnancy to postpartum as standard,
which can be of help to preclinical experiments.

Components & Performance

Smart Planes CNS: Automatically detects fetal brain planes and measurements (BPD, HC, OFD).
Smart Planes FH: Fully automates the detection of major fetal heart planes.
Smart Pelvic: Simplifies the assessment of pelvic floor disorders.
Smart FLC: Fertility assessment with automatic follicle counting.
Smart Face: Generates realistic fetal facial images.
Advanced imaging: iLive: Creates vivid 3D/4D images through realistic lighting and skin effects.
Glass Flow: Renders 2D color flow into a 3D format.
Efficiency features: iWorks: Built-in protocols that shorten exam time by up to 50%. Auto EF and Auto IMT: Automatic measurement functions for cardiac and vascular analysis.
Ergonomic design: Features an ultra-lightweight volume transducer (D8-2E) and a large touchscreen for intuitive use.

Body Composition Analyzer for Rodents

Equipment Description

The whole-body composition analyzer provides a method for precisely measuring muscle mass, fat mass, and body fluid in live rats and mice.
This body composition analyzer boasts the innovative and notable feature of being able to handle animals safely without anesthesia,
thereby setting a new standard for long-term studies.
Since its launch in early 2001, the minispec mouse analyzer (LF
50) has quickly gained market recognition as a powerful, non-destructive, and non-invasive analysis tool for characterization, screening, and phenotyping of mice in research laboratories.
Installed at major pharmaceutical companies, diabetes and obesity research institutes, and universities, it has established itself as an industry standard in the field of measuring fat and muscle mass in mice.

Components & Performance

The minispec body composition analyzer is based on time-domain NMR (TD-NMR) technology. It acquires and analyzes TD-NMR signals from all protons within the entire sample volume, providing values for three main components: fat, body fluid, and muscle mass. This magnetic resonance technology allows researchers to perform multiple measurements during an animal's life cycle, offering the following advantages.
Rapid analysis: Measurement time is less than 2 minutes, with no sample preparation required.
Economical procedure: No consumables required, and expensive laboratory animals can be maintained throughout the study period. The LF50 mouse method analyzes animals up to 60 g. The LF50H mouse analyzer analyzes animals up to 60 g. The LF90II analyzes animals up to approximately 700 g for rats and mice. The LF110 analyzes animals up to approximately 1 kg for rats and mice.
Reduced animal stress: No anesthesia required; animals are measured as is. The reduced risk to animal health allows for more frequent testing. Greater accuracy and precision compared to the DEXA (X-ray) method.

Small Animal Fundus Tomography Camera

Equipment Description

Advanced Optical Coherence Tomography (OCT) systems such as the MICRON OCT2, specialized for in vivo imaging of small animals-particularly rodents-have been developed to provide high-resolution, real-time retinal cross-sectional images for studying conditions such as glaucoma or
diabetic retinopathy, and integrate seamlessly with the company's retinal microscope for comprehensive ophthalmic research.
These systems provide AI-based segmentation, precise targeting, and multimodal imaging, enabling detailed study of retinal structure and function.

Components & Performance

Image-guided method: Overlays OCT scan images onto bright-field images to enable accurate targeting and recording.
Real-time high resolution: Instantly provides detailed 3D images of the retinal layers.
Integrated platform: Works with the MICRON retinal microscope for various imaging needs (fundus, angiography, fluorescence).
Advanced software: Includes AI/deep learning capabilities for automatic segmentation of retinal layers (e.g., identifying up to 10 layers in rodents).
Applications: Used in neuroscience, toxicology, and pharmaceutical research to study vision loss, disease progression, and treatment efficacy.

Comprehensive Lab Animal Monitoring System

Equipment Description

The Comprehensive Lab Animal Monitoring System (CLAMS) equipment simultaneously and non-invasively measures various physiological signals such as energy metabolism, behavior, and body temperature of laboratory animals (mainly rodents),
serving as an integrated monitoring system used in research on metabolic diseases, obesity, and neurological disorders.
It is a core piece of equipment that measures respiratory rate and energy expenditure with oxygen/carbon dioxide sensors, tracks behavioral changes with activity sensors, and precisely analyzes food intake with automatic feeding/watering systems.

Components & Performance

Main components and functions Indirect Calorimetry: Measures oxygen (O₂) consumption and carbon dioxide (CO₂) output within a sealed cage to calculate the animal's energy expenditure (VO2, VCO2), respiratory exchange ratio (RER)
and so on.
Equipment: Oxygen sensor, carbon dioxide sensor, flowmeter, etc.
Activity and behavior analysis: Detects the animal's movement (X, Y, Z axes) via triaxial infrared sensors on the cage floor to analyze activity, sleep patterns, etc.
Equipment: Triple Axis Detection Sensors.
Precise food/water intake measurement: Detects the change in weight of the feeder/water dispenser with a high-precision electronic balance to record intake in real time, even correcting for food waste and feeding behavior.
Equipment: Mettler Toledo electronic balance, feeding/watering management accessories.
Body temperature measurement: Continuously measures the animal's core body temperature via wireless or wired sensors.
Data acquisition and control: Computer software controls all sensors and equipment and collects data. Data is saved in CSV format for visualization and analysis in analysis programs (e.g., GraphPad Prism).
Equipment: Control computer, CI Bus interface. 

Ultra High Frequency Ultrasound Imaging System for Small Animals

Equipment Description

It is the only equipment that uses high-frequency technology to obtain images necessary for basic science in small animals (mice, rats), such as cancer mechanisms, echocardiography, upper abdominal ultrasound, and lower abdominal ultrasound (observation of genitalia).
In addition, in applied science such as targeted genetics research using microbubbles, gene therapy,
and measuring drug efficacy and effects on the heart required in new drug development, it is used to analyze real-time images of laboratory animals in a living state without sacrificing them.

Components & Performance

"1. Vevo 2100™ High-Resolution In Vivo Imaging System
2. Transducer
1) MS-200 : 18 MHz MicroScan transducer
2) MS-250 : 24 MHz MicroScan transducer
3) MS-550D : 55 MHz MicroScan transducer
4) MS-700 : 70MHz MicroScan transducer
3. Software
1) B-Mode
2) ECG-Triggered - Respiration Gated Analysis
3) M-Mode
4) PW Doppler Mode
5) PW Tissue Doppler Mode
6) Color Doppler Mode
7) Power Doppler Mode
8) 3D Mode
9) Contrast Imaging functionality
10) LV Analysis
11) VevoCQ Advanced Contrast
12) Vevo Strain Analysis
4. Accessories
1) Vevo 2100 Imaging Station II
2) Mouse Handling Table
3) Vevo SoniGene System
4) Thermasonics Gel Warmer
5) Anesthesia System for Animal"

Blood Chemistry Analyzer

Equipment Description

Instrument name: Blood Biochemistry Analyzer
Model name: DRI-CHEM 3500S
Dimensions: 400(W) x 385(D) x 280(H) mm
Throughput: 60 tests/hour, 1–6 min/test
Light source: Halogen lamp
Manufacturer: FUJI FILM

Components & Performance

1. Measurable items: 1) Enzyme tests - GGT, GOT/AST, GPT/ALT, CPK, LDH, ALP, AMLY, LAP, CK-MB, CHE
2) General chemistry tests – GLU, BUN, CRE, UA, T-CHOL, NH₃, HDL-C, TG, TBIL, DBIL, CA, MG, IP, TP, ALB, HB
3) Immunology tests – CRP
2. Tube used: sample tube (∅13~16X15~100mm) Fuji tube (0.5ml~1.5ml)
3. sample volume (per test): 10μl or less
4. Calibration: Q.C card system or more than 90 days (daily calibration not required)
5. Reagent type: Fuji Dri-Chem slide (dry reagent type)
6. Specimen samples: Whole blood (GPT/ALT, GLU, BUN, CRE, NH₃, HB), serum, plasma (all items) Urine (AMYL, GLU, UA, CA)
7. Reagent stability: 18 months when refrigerated
8. Quality control: Simple QC card method
9. Dilution cup and diluent set: Automatic dilution at the set ratio

Blood Gas Analyzer

Equipment Description

The pHOx Plus L is a compact point-of-care blood gas analyzer from Nova Biomedical. This equipment is designed to rapidly measure key blood chemistry parameters such as pH, gases, electrolytes, and especially lactate in laboratories,
and is distinguished from the 'C' model which measures calcium and chloride. With its compact size, easy calibration using automatic cartridges, and the ability to provide important animal blood test results from whole blood, capillary blood, and heparinized specimens.

Components & Performance

Key features and operation: Analysis item menu: Depending on configuration, measures pH, blood gases (oxygen, carbon dioxide, etc.), electrolytes, metabolites (including lactate), and hematocrit.
Specimen types: Accepts whole blood, heparinized whole blood, and capillary specimens.
Compact design: Its small size makes it easy to install at the bedside or in a small laboratory.
Automation: Uses automated cartridges (STP pHox Plus L control) for calibration, simplifying quality control.
Use: In vitro diagnostics for monitoring the health and performance of animals. 1. Measurable items: pH, pO2, pCO2, SO2%, Hb, Hct, Na+, K+, Gluc, Lact, (iCa or Cl-)
2. External dimensions: 30 cm (width) × 36 cm (height) × 40 cm (depth)
3. Weight: 20 kg
4. Power: 110-220 VAC / 50-60 Hz (auto switching)
5. Reagent composition: The reagents used in the NOVA STAT Profile pHOx plus are configured as a PACK, with all necessary reagents contained in a single BOX. The reagent PACK consists of 6 reagent bottles and one waste bottle. The A, B, C, D, F, R reagents are used as follows: A and B for pH calibration, C and D for electrolyte calibration, F for flush, and R for reference solution. 6. Testable specimens: Whole blood treated with heparin or anticoagulant (use of sodium and lithium heparin recommended) [*concentration of 20 I.U/ml or less]
7. Sample Handling: Perform the test as soon as possible after sample collection. (※ Measure within 15 minutes after sample collection)

Automatic Urine Chemistry Analyzer

Equipment Description

Instrument name: Automatic Urine Chemistry Analyzer
Model name: Clinitek Advantus; Dimensions: 32.4 cm (width) × 37.7 cm (depth) × 28.2 cm (height)
Manufacturer: SIEMENS.
Power: 100-240 V / 50-60 Hz (auto switching)

Components & Performance

1. Measurable items: Specific Gravity, pH, Protein, Glucose, Bilirubin, Blood, Nitrite, Urobilinogen, Leukocytes, Ketone
2. Light source: Halogen lamp. 3. MEMORY: 500 TEST. 4. CALIBRATION: Automatic calibration is performed for each specimen
5. Urine volume required for measurement: A specimen amount sufficient to fully wet the test pad of the strip
6. Reagent composition QC: “Chek-Stix Combo Pak" - Positive, Negative two control reagents TEST Strip: "Multistix 10SG" - for 100 TESTs
7. Testable specimens: Fresh, non-centrifuged midstream urine

Patient Monitoring System

Equipment Description

This equipment is for monitoring the physiological status of laboratory animals in real time. It continuously measures and displays major vital signs such as heart rate, respiratory rate, blood oxygen saturation, and blood pressure,
enabling accurate assessment of status changes during experiments and supporting safe research execution.

Components & Performance

This equipment is GE's Solar 8000i model, consisting of ECG, SpO₂, non-invasive blood pressure, respiratory rate, and body temperature measurement modules, and can monitor multi-channel vital signs in real time. By continuously displaying and recording each parameter, it allows observation of physiological changes during experiments, and through stable data acquisition and visual alarm functions, it improves the safety and reliability of research.